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Related Concept Videos

Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...

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Related Experiment Video

Updated: Jun 18, 2026

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
11:27

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050

Published on: May 13, 2020

MEROPS: the peptidase database.

Neil D Rawlings1, Alan J Barrett, Alex Bateman

  • 1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. ndr@sanger.ac.uk

Nucleic Acids Research
|November 7, 2009
PubMed
Summary
This summary is machine-generated.

The MEROPS database provides integrated information on peptidases, their substrates, and inhibitors. It classifies these proteins and analyzes cleavage sites, aiding in understanding their biological and medical relevance.

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Last Updated: Jun 18, 2026

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Peptidases, substrates, and inhibitors are crucial in biology, medicine, and biotechnology.
  • An integrated information source is needed for these biomolecules.
  • The MEROPS database serves as this comprehensive resource.

Purpose of the Study:

  • To provide an integrated database of peptidases, substrates, and inhibitors.
  • To classify peptidases and inhibitors hierarchically into species, families, and clans.
  • To detail peptidase specificity and substrate cleavage sites.

Main Methods:

  • Hierarchical classification of homologous peptidases and protein inhibitors.
  • Collection and analysis of over 39,000 known cleavage sites.
  • Development of an analysis tool for comparative genomics of peptidase genes.

Main Results:

  • MEROPS database established with hierarchical classification.
  • Detailed peptidase specificity and substrate cleavage site information provided.
  • Analysis tool identifies gene gains/losses in related species.

Conclusions:

  • The MEROPS database is a valuable resource for understanding peptidase function and evolution.
  • Analysis of cleavage sites aids in determining physiological relevance.
  • Comparative genomic analysis enhances understanding of peptidase gene family dynamics.