Related Experiment Video
Updated: Jun 18, 2026

Analyzing Murine Schwann Cell Development Along Growing Axons
Published on: November 21, 2012
Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: results from experimental stress
Federica Sornelli1, Marco Fiore, George N Chaldakov
1Institute of Neurobiology and Molecular Medicine, CNR-NGF Section, Via del Fosso di Fiorano 64/65, I-00143 Rome, Italy.
Abstract:
Recently, adipobiology (adiposcience) became a focus of numerous studies showing that the adipose tissue is the body's largest endocrine and paracrine organ producing multiple signaling proteins collectively designated adipokines; at present these include more than hundred proteins. However, studies on adipobiology of neurotrophins have recently emerged, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) being examples of adipose-derived neurotrophins. Here we present data showing that NGF and BDNF are expressed in both white and brown adipose tissue following experimental stress (in mice) and in type 1 diabetes (in rats). We suggest that both neurotrophic and metabotrophic potentials of NGF and BDNF may be involved in the molecular mechanism of stress and diabetes and consequently, in the pathogenesis of cardiometabolic diseases.
More Related Videos
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Diabetic Neuropathy
Type II Diabetes II: Pathophysiology
Neurogenesis and Regeneration of Nervous Tissue
Type I Diabetes II: Pathophysiology

