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Updated: Jun 18, 2026
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High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
Published on: February 2, 2024
[Chemical constituents from Corydalis yanhusuo]
Tiantian Hu1, Xue Zhang, Shizhong Ma
1College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Summary
This study identified nine alkaloids from Corydalis yanhusuo, including novel findings for 7-formyldidehydroglaucine and 8-oxocoptisine. These chemical constituents offer new insights into the plant
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Context:
- Corydalis yanhusuo is a traditional medicinal herb.
- Understanding its chemical profile is crucial for pharmacological research.
- Previous studies have identified various compounds, but a comprehensive analysis of its alkaloid content is ongoing.
Purpose:
- To isolate and identify chemical constituents from the 60% ethanol extract of Corydalis yanhusuo.
- To elucidate the structures of isolated compounds using spectroscopic and chemical methods.
Summary:
- Nine alkaloids were isolated and identified: 7-formyldidehydroglaucine (1), nantenine (2), (+)-O-methylbulbocapnine (3), d-corydaline (4), tetrahydrocoptisine (5), 8-oxocoptisine (6), palmatine (7), tetrahydropalmatine (8), and dehydrocorydaline (9).
- Compound 1 represents a new natural product discovery with its NMR data being reported for the first time.
- Compound 3 is reported from the Papaveraceae family for the first time, and compound 6 is newly identified in Corydalis yanhusuo.
Impact:
- This research expands the known chemical diversity of Corydalis yanhusuo.
- The identification of novel compounds and their structural data contributes to the field of natural product chemistry.
- The findings may provide a basis for further investigation into the pharmacological activities of these alkaloids.
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