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Updated: Jun 18, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
[The methodological aspects of the nonmonotonous dose-response dependence]
Abstract:
The methodological foundations of two radiobiological conceptions, the target-theory and the structural-metabolic theory in radiobiology, are discussed. According to the target theory the biologically significant structure (target size) exists in cell, and the dose-response dependence is monotonic. In the structural-metabolic theory, the target appears as the unity of the structure and metabolism. The role of homeostatic mechanisms in nonmonotonic metabolic time-course responses is discussed. The nonmonotonous dose-response dependence of functional and metabolic parameters is due to the nonmonotonous character of time-course response to ionizing radiation.
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