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Updated: Jun 18, 2026

Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

A microfluidic oscillating tube densitometer.

Chloé Marion Coléou1, Philip Dryden, Christopher Harrison

  • 1Schlumberger-Doll Research, 1 Hampshire Street, Cambridge, Massachusetts 02139, USA.

The Review of Scientific Instruments
|November 10, 2009
PubMed
Summary
This summary is machine-generated.

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This study presents a microfluidic oscillating tube densitometer for precise density measurements. The device achieves high accuracy across wide temperature and pressure ranges, simplifying fabrication and calibration.

Area of Science:

  • Analytical Chemistry
  • Physical Chemistry
  • Microfluidics

Background:

  • Traditional densitometers face limitations in accuracy and operational range.
  • Microfluidic devices offer miniaturization and enhanced control for precise measurements.

Purpose of the Study:

  • To develop and validate a microfluidic oscillating tube densitometer.
  • To demonstrate high accuracy density measurements over broad temperature and pressure ranges.

Main Methods:

  • Utilized a microfluidic oscillating tube densitometer with a 20 microl internal volume.
  • Employed novel actuation and detection systems for simplified fabrication.
  • Developed automated calibration methods using air and water.

Main Results:

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Last Updated: Jun 18, 2026

Thermal Measurement Techniques in Analytical Microfluidic Devices
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  • Achieved density accuracy better than +/-0.5% over 50-150°C and 150-15,000 psi.
  • Found the tube's spring constant is temperature-dependent and pressure-insensitive.
  • Observed significant pressure-induced changes in tube volume.

Conclusions:

  • The microfluidic oscillating tube densitometer provides a robust and accurate method for density determination.
  • The device's performance is validated across demanding operational conditions.
  • Understanding the interplay of temperature and pressure on tube properties is crucial for accurate measurements.