Related Experiment Video
Updated: Jun 18, 2026

Murine Dermal Fibroblast Isolation by FACS
Published on: January 7, 2016
The nature of fibrous dysplasia
Liviu Feller1, Neil H Wood, Razia A G Khammissa
1Department of Periodontology and Oral Medicine, University of Limpopo, Pretoria, South Africa. lfeller@ul.ac.za
Abstract:
Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsalpha subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption.
Related Concept Videos
Structural Joints: Fibrous Joints
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
Fibrous Proteins
Cellular Adaptation IV: Dysplasia and Metaplasia
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Introduction to Fibroblasts
Degenerative Disc Disease I: Introduction

