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Updated: Jun 18, 2026

Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
Long-term results of endoscopic treatment of vesicoureteric reflux with different tissue-augmenting substances
Boris Chertin1, Stanislav Kocherov
1Pediatric Urology Unit, Department of Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, P.O. Box 3235, Jerusalem 91031, Israel. boris.chertin@gmail.com
Objective:
To review the current literature regarding the outcome of endoscopic treatment of vesicoureteric reflux (VUR) using different tissue-augmenting substances, with special emphasis on long-term efficacy.
Material And Methods:
The current literature, including our own experience, on long-term results after endoscopic treatment was reviewed by MEDLINE/PubMed search.
Results:
The short-term results are similar in the majority of series to those of open surgery, but there is a high recurrence rate with use of dextranomer/hyaluronic acid (Deflux) as a tissue-augmenting material.
Conclusions:
There is a significant shortage of evidence-based literature on long-term follow-up after endoscopic correction of VUR utilizing dextranomer/hyaluronic acid. The high recurrence rate that has been reported after Deflux injection highlights a need for close observation beyond routine protocols and appropriate parental counseling upon endoscopic correction, and also the need to search further for alternative tissue-augmenting substances. The algorithm for treating VUR is yet to be finally determined.
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