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Preview. Inhibition of Tgf-beta signaling improves mouse fibroblast reprogramming

Knut Woltjen1, William L Stanford

  • 1Ontario Human Induced Pluripotent Stem Cell Facility, Toronto, Canada. woltjen@lunenfeld.ca

Cell Stem Cell
|November 10, 2009
PubMed

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...