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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
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Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

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Related Experiment Video

Updated: Jun 18, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Chronobiological disorders: current and prevalent conditions.

Lia R A Bittencourt1, Rogerio Santos-Silva, Marco T de Mello

  • 1Department of Psychobiology, Universidade Federal de Sao Paulo (UNIFESP), Rua Napoleão de Barros, São Paulo, SP, Brazil.

Journal of Occupational Rehabilitation
|November 10, 2009
PubMed
Summary

Modern lifestyles disrupt sleep quality, leading to circadian rhythm sleep disorders. Treatments like light therapy and melatonin show promise for managing these conditions.

Related Experiment Videos

Last Updated: Jun 18, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Area of Science:

  • Sleep Medicine
  • Chronobiology

Background:

  • Industrialized societies face increased sleep disorders due to hectic lifestyles and artificial light exposure.
  • Circadian Rhythm Sleep Disorders (CRSD) arise from a mismatch between internal biological clocks and external environmental cues.
  • These disorders manifest as insomnia and excessive daytime sleepiness, impacting overall health.

Purpose of the Study:

  • To review the current understanding and diagnostic methods for Circadian Rhythm Sleep Disorders.
  • To provide an overview of established and emerging treatment strategies for CRSD.
  • To highlight the impact of modern lifestyles on sleep patterns and circadian health.

Main Methods:

  • Literature review of sleep disorders and their treatments.
  • Analysis of diagnostic criteria for Circadian Rhythm Sleep Disorders.
  • Summary of therapeutic interventions including chronotherapy, light therapy, and melatonin.

Main Results:

  • Circadian Rhythm Sleep Disorders are a significant consequence of modern living.
  • Diagnosis relies on patient history, sleep logs, and actigraphy.
  • Effective treatments include chronotherapy, timed bright light exposure, and melatonin administration.

Conclusions:

  • Circadian Rhythm Sleep Disorders are prevalent and linked to lifestyle factors.
  • Accurate diagnosis is crucial for effective management.
  • Current treatments offer viable options for restoring circadian alignment and improving sleep quality.