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Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

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Establishing a Device for Sleep Deprivation in Mice
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Published on: September 22, 2023

Sleep Disturbances and Male Reproductive Dysfunction: Pathophysiological Mechanisms Linking Obstructive Sleep Apnea

Tathiana A Alvarenga1, Mariana Toricelli1, Renata Mazaro-Costa2

  • 1Instituto do Sono/Associação Fundo de Incentivo à Pesquisa (AFIP), São Paulo, Brazil.

Comprehensive Physiology
|July 1, 2026
PubMed
Summary

Sleep disturbances like obstructive sleep apnea (OSA) and sleep deprivation negatively impact male fertility by disrupting hormones and increasing oxidative stress. Addressing these sleep issues may improve reproductive health, but more research is needed.

Keywords:
CPAPerectile dysfunctionintermittent hypoxiamale fertilityobstructive sleep apneaoxidative stresssleepsleep deprivationsperm qualitytestosterone

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Published on: October 11, 2018

Area of Science:

  • Reproductive Endocrinology
  • Sleep Medicine
  • Andrology

Background:

  • Sleep disturbances, including obstructive sleep apnea (OSA) and sleep deprivation, are significant but often overlooked causes of male reproductive dysfunction.
  • These conditions disrupt hormonal balance, lowering testosterone and luteinizing hormone, which are crucial for sperm production.

Purpose of the Study:

  • To review the scientific literature on how OSA and sleep deprivation affect male fertility.
  • To explore the underlying endocrine, oxidative stress, and inflammatory mechanisms involved.

Main Methods:

  • A non-systematic narrative review of studies was performed.
  • Databases searched included PubMed/MEDLINE, Scopus, and Web of Science.
  • Focus was on clinical and experimental research examining sleep disturbances and male reproductive health.

Main Results:

  • Sleep disruption and OSA-induced intermittent hypoxia cause oxidative stress, inflammation, and testicular damage.
  • This leads to reduced sperm motility, abnormal sperm shape, and DNA damage.
  • In OSA patients, reproductive issues correlate with the severity of sleep apnea and oxygen levels.

Conclusions:

  • Sleep disturbances are a potentially modifiable factor in male reproductive health.
  • Treatments for sleep disorders and oxidative stress show promise for improving hormonal and physiological markers.
  • Further research is required to confirm the direct impact on fertility and clinical utility.