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Updated: Jun 18, 2026
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[The roles for basophils in allergy].
Kaori Mukai1, Kazushige Obata, Yusuke Tsujimura
1Department of Immune Regulation, Tokyo Medical and Dental University Graduate School.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 11, 2009
Summary
Basophils, though rare immune cells, are critical in allergic reactions and immune system regulation. These findings highlight basophils as key players and potential therapeutic targets for allergies.
Area of Science:
- Immunology
- Cell Biology
Context:
- Basophils are rare leukocytes, often overlooked due to their low numbers and similarity to mast cells.
- Previous research often underestimated the in vivo roles of basophils in immune responses.
Purpose:
- To investigate the underappreciated roles of basophils in immune responses.
- To highlight the significance of basophils in allergic inflammation and immune regulation.
Summary:
- Basophils play crucial roles in IgG-mediated anaphylaxis and IgE-mediated chronic allergic inflammation.
- These cells promote T helper 2 (Th2) differentiation and enhance humoral memory responses.
- Basophils are integral to both immune regulation and allergic responses.
Impact:
- Demonstrates that basophils are key players in vivo, not redundant cells.
- Identifies basophils and their products as promising therapeutic targets for allergic disorders.
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