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Updated: Jun 18, 2026
07:10
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
Published on: April 21, 2019
[Detection of allergen].
Shoko Kobayashi1, Shigeko Inokuma
1Department of Allergy and Rheumatic Diseases, Japanese Red Cross Medical Center.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 11, 2009
Summary
Identifying allergy triggers is crucial. Skin tests and serum tests detect specific IgE, with skin tests generally offering higher sensitivity than blood tests for allergy diagnosis.
Area of Science:
- Immunology
- Allergology
Context:
- Accurate allergen identification is essential for managing allergic conditions.
- Various diagnostic methods exist, each with advantages and disadvantages.
Purpose:
- To review methods for detecting specific IgE antibodies and delayed-type hypersensitivity.
- To compare the efficacy and safety of different allergy testing approaches.
Summary:
- Skin tests, including prick and intradermal tests, are effective for detecting specific IgE, with prick tests recommended before intradermal tests to minimize adverse reactions.
- Skin patch tests are useful for diagnosing delayed-type allergies.
- While skin tests generally show higher sensitivity than serum tests, both have unique merits and demerits.
- The immunological basis of drug allergies requires further investigation.
Impact:
- Provides a comparative overview of allergy diagnostic tools.
- Highlights the importance of selecting appropriate tests based on allergy type and patient factors.
- Underscores areas for future research in drug allergy mechanisms.
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