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Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Physical Properties of Alcohols and Phenols02:32

Physical Properties of Alcohols and Phenols

Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Methods of Sterilization II: Chemical Methods01:30

Methods of Sterilization II: Chemical Methods

In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Structure and Nomenclature of Alcohols and Phenols02:23

Structure and Nomenclature of Alcohols and Phenols

Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...

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Related Experiment Video

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Assessment of Social Interaction Behaviors
06:41

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Published on: February 25, 2011

Aldahol high-level disinfectant.

Norman Miner1, Valerie Harris, Thuy Dung Cao

  • 1MicroChem Laboratory, Inc., 1107-C South Airport Circle, Euless, TX 76040, USA. nminer@microchemlab.net

American Journal of Infection Control
|November 11, 2009
PubMed
Summary

A new disinfectant formulation effectively kills mycobacteria and spore-forming bacteria, including Bacillus subtilis, within practical timeframes at room temperature. This advancement addresses limitations of current disinfectants for medical instruments.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Current high-level disinfectants, glutaraldehyde and ortho-phthalaldehyde (OPA), have limitations in killing mycobacteria and spore-forming bacteria.
  • These limitations may contribute to biofilm formation on medical instruments, complicating disinfection.
  • There is a need for aldehyde-based disinfectants with improved efficacy against resistant microorganisms.

Purpose of the Study:

  • To develop an aldehyde-based disinfectant formulation with enhanced antimicrobial activity.
  • To achieve practical kill times for mycobacteria and spore-forming bacteria at ambient temperatures.
  • To overcome the limitations of existing glutaraldehyde and OPA disinfectants.

Main Methods:

  • Formulations combining glutaraldehyde or OPA with alcohols, salts, chelating agents, and detergents were prepared at alkaline pH.
  • Tested efficacy against cultures of mycobacteria and spore-forming bacteria at 20°C and 25°C.
  • Evaluated sporicidal activity using Bacillus subtilis and mycobacteria kill kinetics.

Main Results:

  • A formulation with 3.5% glutaraldehyde, 20% isopropanol, and 8% potassium acetate demonstrated rapid mycobactericidal activity (6 log(10) reduction in 10 minutes at 20°C).
  • This formulation achieved a 6 log(10) reduction of Bacillus subtilis in suspension within 60 minutes at 20°C.
  • Ortho-phthalaldehyde's sporicidal activity was not significantly enhanced by isopropanol and potassium acetate combinations.

Conclusions:

  • The developed disinfectant, Aldahol high-level disinfectant, effectively kills mycobacteria and Bacillus subtilis within practical timeframes.
  • This formulation offers an improved solution for disinfecting heat-sensitive medical instruments, addressing limitations of current agents.
  • The study highlights the potential of synergistic combinations in enhancing aldehyde-based disinfectant efficacy.