Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma-Derived Extracellular Vesicle-Enriched Fractions as a Potential Source of Biomarkers for Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): A Shotgun Proteomic Exploration Analysis.

Diagnostics (Basel, Switzerland)·2026
Same author

Proteomics in myelodysplastic syndromes: towards novel prognostic and diagnostic biomarkers.

Biochemia medica·2026
Same author

The biomarkers uCTX-II, CS846 and IGF-1 are associated with clinical and ultrasound scores in haemophilic arthropathy: a cross-sectional study.

Rheumatology international·2026
Same author

Proteomics-Based Study of Potential Emphysema Biomarkers Reveals Systemic Redox System and Extracellular Matrix Component Dysregulation.

Diagnostics (Basel, Switzerland)·2026
Same author

Bone Induction as a Function of Size and Chemical Composition of Calcium Phosphate Granules in Osteogrow-C Evaluated in Animal Models: A 1-Year Follow-Up.

Biomaterials research·2026
Same author

Role of Cytokines in Wound Healing Following Wound Catheter Analgesia in Rats.

Veterinary sciences·2025
Same journal

Retinoid dynamics in immune cells during age-related diseases.

Cytokine & growth factor reviews·2026
Same journal

The functional roles of macrophage migration inhibitory factor in the tumor microenvironment.

Cytokine & growth factor reviews·2026
Same journal

Tissue-resident immune cells in tumors: Cytokine-mediated regulation, functional plasticity, and therapeutic opportunities.

Cytokine & growth factor reviews·2026
Same journal

Shared and context-specific mechanisms of T cell exhaustion in chronic viral infections and cancer: Transcriptional, metabolic, epigenetic, and therapeutic perspectives.

Cytokine & growth factor reviews·2026
Same journal

Temporal dynamics of type I interferon signaling in checkpoint inhibitor response and resistance.

Cytokine & growth factor reviews·2026
Same journal

The role of osteoprotegerin in colorectal cancer: Molecular interactions, mechanistic insights, and therapeutic implications.

Cytokine & growth factor reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
09:53

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Published on: July 15, 2016

BMP-6 and mesenchymal stem cell differentiation.

Slobodan Vukicevic1, Lovorka Grgurevic

  • 1Laboratory of Mineralized Tissues, Center for Translational Research, School of Medicine, University of Zagreb, Salata 5, 10000 Zagreb, Croatia. vukicev@mef.hr

Cytokine & Growth Factor Reviews
|November 11, 2009
PubMed
Summary
This summary is machine-generated.

Bone morphogenetic protein-6 (BMP-6) is crucial for bone regeneration and iron homeostasis. BMP-6 deficiency in mice leads to iron overload and diabetes-like symptoms, highlighting its systemic importance.

More Related Videos

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells
06:24

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells

Published on: October 20, 2023

Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats
08:58

Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats

Published on: August 25, 2020

Related Experiment Videos

Last Updated: Jun 18, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
09:53

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Published on: July 15, 2016

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells
06:24

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells

Published on: October 20, 2023

Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats
08:58

Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats

Published on: August 25, 2020

Area of Science:

  • Biochemistry
  • Cell Biology
  • Endocrinology

Background:

  • Bone morphogenetic protein-6 (BMP-6) is produced by mesenchymal and hematopoietic stem cells, contributing to tissue differentiation.
  • BMP-6 plays a role in bone metabolism, acting as a coupling factor between osteoclasts and osteoblasts.
  • BMP-6 deficiency in mice results in iron overload and potential diabetes, indicating systemic effects.

Purpose of the Study:

  • To elucidate the multifaceted roles of BMP-6 in bone regeneration and systemic iron regulation.
  • To investigate the therapeutic potential of BMP-6 in bone defect repair compared to other BMPs.

Main Methods:

  • Analysis of Bmp6-/- null mice to assess iron metabolism and glucose levels.
  • Observation of BMP-6 production by bone marrow-derived stem cells (BMSC) and osteoclasts.
  • Comparative studies on the efficacy of BMP-6 versus BMP-7 in animal models for bone defect regeneration.

Main Results:

  • Bmp6-/- mice exhibit low hepcidin levels, iron overload, and impaired glucose regulation.
  • BMP-6 is secreted by BMSC before osteoblast differentiation and by osteoclasts during bone resorption.
  • Lower concentrations of BMP-6 than BMP-7 are effective in inducing bone defect regeneration in vivo.

Conclusions:

  • BMP-6 is essential for maintaining iron homeostasis and pancreatic beta-cell function.
  • BMP-6 is a key regulator of bone remodeling and a potent factor for bone regeneration.
  • BMP-6 demonstrates superior efficacy and potentially lower dosage requirements for bone regeneration compared to BMP-7.