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Autoimmune polyglandular syndrome type 2 with myasthenia gravis crisis
Shingo Konno1, Takamasa Ichijo, Mayumi Murata
1Division of Neurology, and daggerDepartment of Internal Medicine, Division of Diabetes, Toho University Ohashi Medical Center, Tokyo, Japan. d500372@oha.toho-u.ac.jp
Abstract:
We describe a rare case of autoimmune polyglandular syndrome type 2 initially presenting as Addison disease and autoimmune thyroid disease, with subsequent development of autoimmune hepatitis and myasthenia gravis (MG) crisis in a Japanese woman. MG improved with oral prednisolone followed by plasmapheresis for immunoadsorption; thymectomy was not performed. Conventional treatment for MG was effective and safe in this case, in which there was positivity for human leukocyte antigen A23, B52, B62, DR11, and DR15.
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