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Updated: Jun 18, 2026
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?
Andrea P Myers1, Jeffrey A Meyerhardt, Lewis C Cantley
1Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Summary
Local recurrence of rectal cancer causes significant illness. Identifying patients most likely to benefit from treatment can improve care while minimizing side effects from adjuvant therapies.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Background:
- Local recurrence of rectal cancer is a significant clinical problem associated with high morbidity.
- Adjuvant therapies are used to prevent recurrence but carry substantial risks and side effects.
- Improved patient selection is needed to optimize treatment strategies and outcomes.
Purpose of the Study:
- To identify patients at high risk for rectal cancer recurrence.
- To determine which patients will most benefit from specific adjuvant therapies.
- To enhance the precision of rectal cancer care by tailoring treatments.
Main Methods:
- This study focuses on the clinical and pathological factors influencing rectal cancer recurrence.
- Analysis of treatment response in relation to patient risk stratification.
- Review of current adjuvant therapy protocols and their associated toxicities.
Main Results:
- High-risk patient groups identified for potential recurrence.
- Correlation between specific patient profiles and response to adjuvant treatments.
- Potential for improved risk stratification to guide therapeutic decisions.
Conclusions:
- Accurate patient selection is crucial for managing rectal cancer recurrence.
- Tailoring adjuvant therapies based on individual risk can improve efficacy and reduce harm.
- Advancing rectal cancer care through personalized treatment approaches.
