Related Experiment Video
Updated: Jun 18, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical
Nicolas Ducros1, Lionel Hervé, Anabela Da Silva
1CEA, LETI, MINATEC, 17 rue des Martyrs, F-38054 Grenoble, France. nicolas.ducros@cea.fr
Abstract:
The problem of fluorescence diffuse optical tomography consists in localizing fluorescent markers from near-infrared light measurements. Among the different available acquisition modalities, the time-resolved modality is expected to provide measurements of richer information content. To extract this information, the moments of the time-resolved measurements are often considered. In this paper, a theoretical analysis of the moments of the forward problem in fluorescence diffuse optical tomography is proposed for the infinite medium geometry. The moments are expressed as a function of the source, detector and markers positions as well as the optical properties of the medium and markers. Here, for the first time, an analytical expression holding for any moments order is mathematically derived. In addition, analytical expressions of the mean, variance and covariance of the moments in the presence of noise are given. These expressions are used to demonstrate the increasing sensitivity of moments to noise. Finally, the newly derived expressions are illustrated by means of sensitivity maps. The physical interpretation of the analytical formulae in conjunction with their map representations could provide new insights into the analysis of the information content provided by moments.
Related Concept Videos
Imaging Studies III: Computed Tomography
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview
The ATR process begins by directing a beam...
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Total Internal Reflection Fluorescence Microscopy
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
