Related Experiment Video

Updated: Jun 18, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Considerations in choosing screening conditions: one (US) approach

Bradford L Therrell1

  • 1Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. therrell@uthscsa.edu

Annals of the Academy of Medicine, Singapore
|November 12, 2009
PubMed

Insights

The United States lacks a national newborn screening policy, leading to varied state guidelines. This report details the development of national recommendations for newborn screening tests and selection criteria.

Area of Science:

  • Genetics
  • Public Health
  • Pediatrics

Background:

  • The United States has 51 distinct newborn screening (NBS) policies due to the absence of a national strategy.
  • A 2000 American Academy of Pediatrics report proposed a national blueprint for NBS.
  • This led to federal initiatives to standardize NBS practices nationwide.

Purpose of the Study:

  • To outline the development of a national decision-making algorithm for selecting conditions for NBS panels.
  • To present the recommended panel of screening tests for state implementation.
  • To summarize the processes and outcomes guiding current US NBS recommendations.

Main Methods:

  • A working group developed a national NBS blueprint.
  • The Health Resources and Services Administration contracted the American College of Medical Genetics.
  • An algorithm for condition selection and a recommended test panel were created.

Main Results:

  • Development of a systematic algorithm for choosing NBS conditions.
  • Establishment of a recommended panel of screening tests for national guidance.
  • Summarization of the collaborative process leading to current NBS standards.

Conclusions:

  • The developed algorithm and recommended panel provide a framework for consistent NBS across the US.
  • These efforts aim to improve early detection and management of genetic disorders in newborns.
  • The report synthesizes the foundational work for current US newborn screening recommendations.

More Related Videos

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Cochran's Q Test01:17

Cochran's Q Test

Cochran's Q Test is a nonparametric statistical test used to determine if there are potential differences in the outcomes of three or more related groups on a binary (yes/no) or dichotomous outcome. It is essentially an extension of the McNemar Test, which is limited to two related samples - Cochran's Q test can handle three or more related samples, making it more versatile in scenarios where subjects are measured under multiple conditions. The test statistic follows a Chi-Square distribution,...