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Updated: Jun 18, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
CD40/CD40L signaling and its implication in health and disease
Antonios Chatzigeorgiou1, Maria Lyberi, Gregorios Chatzilymperis
1Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B-cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases.
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