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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: Jun 18, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

SynergEyes lenses for keratoconus.

Yasmine F Abdalla1, Ahmad F Elsahn, Kristin M Hammersmith

  • 1Cornea Service, Wills Eye Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Cornea
|November 13, 2009
PubMed
Summary

SynergEyes hybrid contact lenses offer a successful alternative for keratoconus and pellucid marginal degeneration patients struggling with rigid gas permeable lenses. The study showed an 86.9% success rate, improving vision for many.

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Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
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Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

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Last Updated: Jun 18, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
05:46

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Area of Science:

  • Ophthalmology
  • Corneal Disease Management
  • Optometry

Background:

  • Keratoconus (KC) and pellucid marginal degeneration (PMD) are progressive corneal conditions often requiring specialized contact lens correction.
  • Rigid gas permeable (RGP) lenses are a common solution, but intolerance or fitting challenges exist for some patients.

Purpose of the Study:

  • To evaluate the initial clinical outcomes of fitting SynergEyes hybrid contact lenses.
  • To assess the efficacy of SynergEyes lenses as a visual rehabilitation option for patients with KC and PMD.

Main Methods:

  • Retrospective chart review of patients fitted with SynergEyes lenses over a 7-month period.
  • Analysis of patient demographics, indications for lens fitting, refitting requirements, and success rates.

Main Results:

  • 86.9% success rate in 61 eyes (44 patients) with KC or PMD.
  • Primary indication was rigid gas permeable (RGP) lens intolerance (50.8%).
  • Lens failures were mainly due to discomfort or unsatisfactory vision within the first two months.

Conclusions:

  • SynergEyes hybrid lenses represent a viable and promising alternative for visual rehabilitation.
  • These lenses can benefit patients with KC and PMD who cannot tolerate or be successfully fitted with RGP lenses.