Related Experiment Video
Updated: Jun 18, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
SynergEyes lenses for keratoconus
Yasmine F Abdalla1, Ahmad F Elsahn, Kristin M Hammersmith
1Cornea Service, Wills Eye Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Purpose:
To discuss the initial results of fitting SynergEyes hybrid contact lenses (SynergEyes, Inc, Carlsbad, CA) for keratoconus (KC) and pellucid marginal degeneration (PMD).
Methods:
The charts of patients fit with SynergEyes lenses during the first 7 months the lens was available on the Cornea Service at Wills Eye Institute (August 3, 2006 to March 5, 2007) were retrospectively reviewed.
Results:
Sixty-one eyes (44 patients) with KC (58 eyes) or PMD (3 eyes) were fit with SynergEyes hybrid contacts. The mean age was 40 +/- 12.6 years; the mean follow-up period was 7.8 +/- 4.6 months. The most common indication for SynergEyes was rigid gas permeable (RGP) lens intolerance, 31 of 61 eyes (50.8%). Inability to fit with RGP was the indication in 8 eyes (13.1%), and 22 eyes (36%) were refit from SoftPerm (Ciba Vision, Corp, Duluth, GA). Twenty-two patients required refitting, including 17 base curve changes and 5 skirt changes. The success rate was 86.9% (53 of 61 eyes). Most failures (8 eyes of 6 patients) discontinued the lens within the first 1-2 months because of discomfort (5 eyes) or unsatisfactory vision (3 eyes).
Conclusion:
SynergEyes lenses are a promising alternative for visual rehabilitation in patients with KC and PMD who are intolerant or unable to be fit in RGP lenses.
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