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Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

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Contact Lens-Related Corneal Infections.

Taylor J Linaburg¹, Kristin M Hammersmith¹

¹Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, 51 North 39th Street, Philadelphia, PA 19104, USA.

Infectious Disease Clinics of North America

|September 13, 2024

Summary

This summary is machine-generated.

Contact lens-associated microbial keratitis (MK) is a serious eye infection. Proper hygiene and avoiding overnight wear are crucial for preventing this vision-threatening condition.

Keywords:

Acanthamoeba keratitis Bacterial keratitis Contact lens Contact lens-related microbial keratitis Fungal keratitis Microbial keratitis Pseudomonas keratitis

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Area of Science:

Ophthalmology
Microbiology

Background:

Microbial keratitis (MK) is a significant cause of vision impairment.
Contact lens wear is a primary risk factor for developing MK.

Purpose of the Study:

To provide an updated review of contact lens-associated microbial keratitis (CL-MK).
To discuss prevalence, risk factors, causative organisms, clinical presentation, and treatment strategies for CL-MK.

Main Methods:

Literature review of current research on contact lens-associated microbial keratitis.
Analysis of prevalence, risk factors, and etiological agents.
Summary of clinical manifestations and therapeutic approaches.

Main Results:

Bacterial pathogens are the most common cause of CL-MK, followed by fungi and protozoa.
Overnight wear, poor hygiene, and specific contact lens types increase MK risk.
Symptoms include pain, redness, and vision loss, varying with the causative organism.

Conclusions:

Preventive measures, including strict hygiene and avoiding overnight wear, are essential.
Prompt diagnosis and appropriate antimicrobial therapy (antibiotic, antifungal, antiprotozoal) are critical.
Surgical intervention is reserved for severe, non-responsive cases of CL-MK.