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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

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Related Experiment Video

Updated: Jun 18, 2026

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
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Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

Peripheral nerve regeneration: a current perspective.

Christine Radtke1, Peter M Vogt

  • 1Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, 30625 Hannover, Carl-Neuberg Strasse 1, Hannover, Germany. Radtke.Christine@MH-Hannover.de

Eplasty
|November 13, 2009
PubMed
Summary
This summary is machine-generated.

Olfactory ensheathing cells promote axonal regeneration and functional recovery in peripheral nerve repair. This cell therapy, when used with microsurgery, enhances nerve healing and remyelination.

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Last Updated: Jun 18, 2026

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
09:17

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
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Published on: October 20, 2021

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Nerve regeneration is challenging; cell therapies aim to improve axonal regrowth.
  • Peripheral myelin-forming cells, like Schwann cells and olfactory ensheathing cells, support regeneration and remyelination.

Purpose of the Study:

  • Review basic properties of myelinated axon regeneration.
  • Examine functional improvements after peripheral myelinating cell transplantation in spinal cord injury.
  • Evaluate olfactory ensheathing cells as adjunct therapy for peripheral nerve microsurgical repair.

Main Methods:

  • Transplantation of olfactory ensheathing cells into injured rat sciatic nerves during microsurgical repair.
  • Histological and behavioral assessments at 5 weeks post-surgery.

Main Results:

  • Olfactory ensheathing cell transplantation enhanced axonal regeneration across the repair site.
  • Improved functional outcomes were observed in experimental groups.

Conclusions:

  • Olfactory ensheathing cells integrate and aid neural repair in spinal cord and peripheral nerves.
  • They promote axonal sprouting and remyelination, crucial for nerve impulse conduction.
  • Adjunct cell transplantation with microsurgery is a promising strategy for peripheral nerve repair.