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Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jun 18, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

[Wheat-dependent, exercise-induced anaphylaxis].

R Brans¹, H Ott, H F Merk

¹Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. rbrans@ukaachen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|November 13, 2009

Summary

This summary is machine-generated.

Wheat-dependent exercise-induced anaphylaxis (WDEIA) may be more common than previously thought. Diagnosing WDEIA requires specific IgE testing for the recombinant Tri a 19 protein, not standard allergy tests.

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Measuring Local Anaphylaxis in Mice

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Published on: October 14, 2014

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Area of Science:

Allergy and Immunology
Food Hypersensitivity
Clinical Medicine

Background:

Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare condition triggered by wheat ingestion followed by exercise.
Omega-5-Gliadin (Tri a 19) is identified as the primary allergen responsible for WDEIA.

Observation:

Presents three clinical cases of WDEIA.
Highlights that WDEIA might be underdiagnosed.

Findings:

Standard allergy tests like prick tests or IgE to allergen extracts are insufficient for WDEIA diagnosis.
Detection of specific IgE against the recombinant protein Tri a 19 is crucial for accurate diagnosis.

Implications:

Suggests a higher prevalence of WDEIA than currently recognized.
Emphasizes the importance of specific IgE testing for Tri a 19 in diagnosing WDEIA.
Recommends revised diagnostic approaches for suspected WDEIA cases.