Related Experiment Video
Updated: Jun 18, 2026

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
Published on: October 6, 2015
Mathematical model for optimal use of sulfadoxine-pyrimethamine as a temporary malaria vaccine
Bassidy Dembele1, Avner Friedman, Abdul-Aziz Yakubu
1Department of Mathematics and Computer Science, Grambling State University, Grambling, LA 71245, USA. dem_77@hotmail.com
Abstract:
In this paper, we introduce a deterministic malaria model for determining the drug administration protocol that leads to the smallest first malaria episodes during the wet season. To explore the effects of administering the malaria drug on different days during the wet season while minimizing the potential harmful effects of drug overdose, we define 40 drug administration protocols. Our results fit well with the clinical studies of Coulibaly et al. at a site in Mali. In addition, we provide protocols that lead to smaller number of first malaria episodes during the wet season than the protocol of Coulibaly et al.
More Related Videos
07:39An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells
Published on: August 15, 2012
10:50Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis
Published on: November 2, 2018
Related Concept Videos
Malaria
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Pharmacodynamic Models: Additive and Proportional Drug Effect Model
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.