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Published on: November 30, 2016
Celiac disease in patients with presumed irritable bowel syndrome: a case-finding study
Khaled Ali Jadallah1, Yousef Saleh Khader
1Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. khaled-j@just.edu.jo
Aim:
To estimate the prevalence of celiac disease (CD) in adult patients with presumed irritable bowel syndrome (IBS).
Methods:
Between March 2005 and December 2008, 742 consecutive patients (293 male, median age 43 years, range 18-69 years) fulfilling the Rome II criteria for IBS were prospectively enrolled in the study. IBS was diagnosed via self-completed Rome II modular questionnaires. Anti-tissue transglutaminase (anti-tTG) serology was checked to initially recognize possible CD cases. Patients with a positive test were offered endoscopic duodenal biopsy to confirm the diagnosis of CD.
Results:
Thirty two patients (15 male, median age 41 years, range 19-59 years) were found to have organic diseases other than CD. Twenty four patients tested positive for anti-tTG antibodies, and duodenal biopsies confirmed the diagnosis in all of them. Thus, in this patient population with presumed IBS, 3.23% actually had CD.
Conclusion:
CD is common in patients with presumed IBS. Routine screening for CD in patients with symptoms of IBS is recommended.
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