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Updated: Jun 18, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Potential role for ligand-gated ion channels after seizure-induced neurogenesis
Ann Swijsen1, Govert Hoogland, Jean-Michel Rigo
1BIOMED Research Institute, Hasselt University and transnationale Universiteit Limburg, B-3590 Diepenbeek, Belgium.
Abstract:
Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work, however, suggests an aberrant incorporation of newborn cells into the existing hippocampal network in such a way that they promote hippocampal hyperexcitability. In the present review, we discuss current knowledge about the possible role of seizure-induced newly generated neurons and the putative involvement of ligand-gated ion channels in the process of epileptogenesis.
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