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A double-blind controlled comparison of generic and trade-name topical steroids using the vasoconstriction assay
1Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Abstract:
Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay.
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