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Corticosteroid-induced juxta-articular adiposis dolorosa
1Department of Dermatology, Jefferson Medical College, Philadelphia, Pa. 19107.
Archives of Dermatology
|February 1, 1991
Summary
Long-term high-dose corticosteroid use can cause fat deposition and obesity. This case report details adiposis dolorosa as a rare complication of prednisone treatment, potentially linked to altered fat metabolism.
Area of Science:
- Endocrinology and Metabolism
- Clinical Pharmacology
Background:
- High-dose corticosteroid therapy is associated with adverse effects, including altered fat distribution.
- Truncal obesity and focal fatty deposition are known complications of prolonged corticosteroid use.
Observation:
- A patient with L-tryptophan-associated eosinophilia-myalgia syndrome developed juxta-articular adiposis dolorosa.
- The patient was treated with high doses of prednisone, a common corticosteroid.
Findings:
- This is the first reported case of adiposis dolorosa as a complication of corticosteroid treatment.
- Corticosteroid excess may induce alterations in fat metabolism, contributing to this painful syndrome.
Implications:
- Highlights a rare but significant complication of long-term, high-dose corticosteroid therapy.
- Suggests a need for vigilance regarding fat metabolism disturbances in patients on prolonged corticosteroid treatment.
- May prompt further research into the mechanisms linking corticosteroids to adiposis dolorosa.