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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity.

Haijia Yu1, Chuanqi Zhao, Yong Chen

  • 1Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.

Journal of Medicinal Chemistry
|November 17, 2009
PubMed
Summary

Chiral supramolecular complexes selectively bind G-quadruplex DNA. DNA loop sequences, particularly adenine, dictate this selectivity, influencing G-quadruplex structural transitions and showing potential in cancer therapy.

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