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Updated: Jun 18, 2026

Laser Microdissection Applied to Gene Expression Profiling of Subset of Cells from the Drosophila Wing Disc
Published on: April 30, 2010
Size regulation in the segmentation of Drosophila: interacting interfaces between localized domains of gene
Sergei Vakulenko1, Manu, John Reinitz
1Institute of Mechanical Engineering Problems, Institute of Print, St. Petersburg, Russia.
Abstract:
We propose a new mechanism for robust biological patterning. The mechanism bears analogy to interface dynamics in condensed media. We apply this method to study how gene networks control segmentation of Drosophila. The proposed model is minimal involving only 4 genes and a morphogen gradient. We discuss experimental data for which developmental genes are expressed within domains spatially limited by kinks (interfaces) and the gene interaction scheme contains both weak and strong repulsion. We show how kink-kink interactions can be calculated from the gene interactions and how the gene interaction scheme ensures the control of proportions (size regulation).
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