Related Experiment Video
Updated: Jun 18, 2026

Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans
Published on: March 23, 2019
Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria
Abdelmounaaïm Allaoui1, Anne Botteaux, Jacques E Dumont
1Laboratoire de Bactériologie Moléculaire, Université Libre de Bruxelles (ULB), Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium.
Abstract:
Among the host defense mechanisms against bacteria, leukocyte phagocytosis leads to their hydrogen peroxide (H(2)O(2))-mediated destruction. The recent discovery of dual oxidase (DUOX)-dependent H(2)O(2) generation associated with peroxidase and thiocyanate secretion at the apex of mucosal cells has been similarly interpreted as a killing mechanism. However, the rapid degradation of H(2)O(2) would be expected to reduce the efficiency of this system. It has been demonstrated that H(2)O(2) acts as a chemorepellent for bacteria, and such an effect might be sufficient to block cellular infection. Therefore, H(2)O(2) generation might represent one of the mechanisms that allows the coexistence of mucosae with potentially harmful bacteria. Here, we discuss the possible role of DUOXes and H(2)O(2) in interactions between host mucosae and bacteria to maintain mucosal homeostasis.
More Related Videos
16:41Detecting, Visualizing and Quantitating the Generation of Reactive Oxygen Species in an Amoeba Model System
Published on: November 5, 2013
08:57Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
Related Concept Videos
The Oral Microbiota
Microbiota of the Respiratory Tract
Microbial Interactions: Mutualism
Oxygen Requirements and Growth Patterns
Electron Transport Chain: Complex III and IV
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...