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Neuropeptide Y polymorphisms and ischemic stroke in Chinese population
Jin-Tai Yu1, Nan-Nan Yu, Si-Shan Gao
1Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 17, 2009
Summary
Neuropeptide Y (NPY) gene polymorphisms are linked to ischemic stroke risk. Specifically, the -399C allele in the NPY gene is an independent risk factor for stroke, particularly in small vessel disease subtypes.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Diseases
Background:
- Stroke is a leading cause of death and disability globally.
- Emerging evidence suggests Neuropeptide Y (NPY) may play a role in ischemic stroke.
- Investigating genetic factors in stroke etiology is crucial for understanding disease mechanisms.
Purpose of the Study:
- To investigate the association between functional polymorphisms in the NPY gene promoter and ischemic stroke risk.
- To identify specific NPY gene variants that may predispose individuals to stroke.
- To explore the role of NPY in stroke pathology.
Main Methods:
- A case-control study involving 450 ischemic stroke patients and 423 healthy Han Chinese controls.
- Genotyping of three functional polymorphisms (-883TGins/del, -602G/T, -399 T/C) in the NPY gene promoter using DNA sequencing.
- Statistical analysis including logistic regression and haplotype analysis.
Main Results:
- The -399CC genotype and -399C allele of the NPY gene were significantly more frequent in ischemic stroke patients compared to controls.
- These associations were particularly pronounced in the small vessel disease (SVD) subtype of stroke.
- Haplotype analysis identified the -883ins/-399C haplotype as a significant risk marker for ischemic stroke.
Conclusions:
- The C allele of the -399 T/C polymorphism in the NPY gene promoter is an independent risk factor for ischemic stroke.
- These findings suggest that the NPY system is involved in the pathological mechanisms of stroke.
- Genetic variations in NPY may contribute to stroke susceptibility.
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