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Antioxidant isolated from Schisandra propinqua (Wall.) Baill
Feng Huang1, Lijia Xu, Shi Ganggang
1Medical College, Shantou University, Guangdong, China 515031.
Biological Research
|November 17, 2009
Summary
Schisandra propinqua stems exhibit potent antioxidant properties. Extracts and a novel compound effectively scavenge free radicals, supporting its traditional medicinal use.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products
Background:
- Schisandra propinqua is a traditional Chinese folk medicine.
- Its stems are utilized for various medicinal purposes.
Purpose of the Study:
- To isolate and characterize bioactive compounds from Schisandra propinqua stems.
- To investigate the antioxidant activities of these compounds in vitro.
Main Methods:
- Activity-guided fractionation of ethanol extract from S. propinqua stems.
- Isolation and structural elucidation of a neolignan compound.
- In vitro assays for DPPH, superoxide anion, and hydroxyl radical scavenging.
- Assessment of lipid peroxidation inhibition.
Main Results:
- A neolignan, 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol, was isolated.
- Extracts and the pure compound demonstrated significant free radical scavenging activity.
- Inhibition of lipid peroxidation was observed.
Conclusions:
- The antioxidant activities of Schisandra propinqua support its traditional medicinal applications.
- The EtOAc fraction of S. propinqua stems is a valuable source of natural antioxidants.