Related Experiment Video
Updated: Jun 18, 2026
07:11
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
Endothelial dysfunction in peritoneal dialysis patients with and without failed renal transplants
N Gorgulu1, B Yelken, Y Caliskan
1Istanbul University, Istanbul School of Medicine, Department of Internal Medicine, Istanbul, Turkey. numangorgulu@gmail.com
Transplantation Proceedings
|November 18, 2009
Summary
Endothelial dysfunction (ED) is more pronounced in patients with failed renal transplants restarting peritoneal dialysis (fTxPD) compared to those on peritoneal dialysis (PD) without prior transplants. This suggests a failed allograft may contribute to ED development in fTxPD patients.
Area of Science:
- Nephrology
- Cardiology
- Vascular Biology
Background:
- Endothelial dysfunction (ED) is an early indicator of atherosclerosis and cardiovascular events.
- Inflammation is linked to atherosclerosis and malnutrition, common in transplant patients.
- ED has not been well-characterized in patients with failed renal transplants restarting peritoneal dialysis (fTxPD).
Purpose of the Study:
- To investigate and compare endothelial dysfunction (ED) in naive peritoneal dialysis (nPD) patients and fTxPD patients.
- To assess potential confounding factors including inflammation markers and dialysis adequacy.
Main Methods:
- A cross-sectional study comparing 25 nPD patients and 12 fTxPD patients.
- Endothelial dysfunction (ED) was evaluated using coronary flow reserve (CFR) measurements.
- Serum markers (creatinine, calcium, phosphorus, cholesterol, albumin, hemoglobin, iPTH) and hs-CRP were measured.
Main Results:
- No significant differences in demographics, blood pressure, or dialysis parameters between nPD and fTxPD groups.
- fTxPD patients exhibited significantly higher hs-CRP levels (indicating inflammation).
- fTxPD patients showed significantly lower CFR, indicating more prominent ED.
Conclusions:
- Endothelial dysfunction (ED) is more prevalent in fTxPD patients compared to nPD patients.
- A failed renal allograft is suggested as a potential cause of increased ED in fTxPD patients.
Related Concept Videos
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
01:25Peritoneal Dialysis III: Nursing Management
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
01:27Dialysis
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
01:30Peritoneal Dialysis I: Introduction and Procedure
Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
01:25Hemodialysis I: Introduction
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...