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[Cutaneous large B-cell leg-type lymphoma occurring on a leg burn]
M Meziane1, S Hesse, B Chetaille
1Service de dermatologie, CHU de La Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. mariame.meziane@yahoo.fr
Annales De Dermatologie Et De Venereologie
|November 18, 2009
Summary
This study reports a rare case of leg-type primary cutaneous large B-cell lymphoma developing in a burn scar. The findings suggest burn site injury and immune dysregulation may contribute to lymphoma development.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Primary cutaneous B-cell lymphomas (PCBCLs) are diverse skin lymphoid neoplasms.
- This report details a rare instance of leg-type PCBCL arising in a burn scar.
Observation:
- An 85-year-old male presented with ulcerative lesions on a 17-year-old leg burn scar.
- Biopsies revealed atypical large lymphoid cells with B-cell phenotype (MUM1/IRF4+, BCL2+, BCL6 weak+, CD10-).
- Staging showed tibial bone involvement; initial treatment with chemotherapy and rituximab yielded temporary regression.
Findings:
- This is the first reported case of leg-type primary cutaneous large B-cell lymphoma occurring on burn scar tissue.
- The lymphoma cells exhibited an immunoblastic or centroblastic morphology.
- Immunohistochemistry confirmed B-cell phenotype.
Implications:
- The development of this lymphoma may be linked to the burn injury and subsequent immune dysregulation at the scar site.
- Previous research implicated venous insufficiency and lymphatic stasis in similar lymphomas.
- This case highlights a potential novel risk factor for cutaneous lymphoma development.
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