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Related Experiment Video

Updated: Jun 18, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

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Published on: April 24, 2020

Headache in normal-tension glaucoma patients.

S Orgül¹, J Flammer

¹University Eye Clinic Basel, Basel, Switzerland.

Journal of Glaucoma

|November 19, 2009

Summary

Headache may indicate a specific subgroup of normal-tension glaucoma (NTG) patients. NTG patients with headaches had significantly lower intraocular pressure (IOP) than those without headaches.

Area of Science:

Ophthalmology
Neurology

Background:

Headache, including migraine, is a potential risk factor for normal-tension glaucoma (NTG).
The relationship between headache and NTG, independent of intraocular pressure (IOP), requires clarification.

Purpose of the Study:

To compare intraocular pressure (IOP) between normal-tension glaucoma (NTG) patients with and without headaches.
To investigate if headache is an independent factor associated with lower IOP in NTG.

Main Methods:

Compared mean IOP in NTG patients with (n=14) and without (n=9) headache.
Performed an analogous comparison in non-glaucomatous control subjects (n=23) with (n=13) and without (n=10) headache.
Ensured glaucoma and control groups were matched for sex, age, and mean IOP.

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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Main Results:

NTG patients with headache exhibited significantly lower mean IOP (p = 0.0004) compared to NTG patients without headache.
This IOP difference was observed despite comparable glaucomatous visual-field damage in both NTG subgroups.
No significant IOP difference was found between headache and non-headache groups in non-glaucomatous controls.

Conclusions:

Headache appears to identify a distinct subgroup within the normal-tension glaucoma population.
The findings suggest headache may be associated with lower intraocular pressure in NTG, independent of visual field status.