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Effect of topical flurbiprofen on trabeculectomy
L B Cantor1, C A Phillips, D Kramer
1Department of Ophthalmology * Department of Biostatistics. Indiana University School of Medicine, Indianapolis, Indiana, U.S.A.
Journal of Glaucoma
|November 19, 2009
Summary
Postoperative flurbiprofen did not improve outcomes after trabeculectomy surgery. This non-steroidal anti-inflammatory drug did not significantly affect intraocular pressure or visual acuity in glaucoma patients.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Pharmacology
Background:
- Trabeculectomy is a common surgical procedure for glaucoma.
- Postoperative care often includes anti-inflammatory medications.
- The efficacy of adding flurbiprofen to standard postoperative regimens requires investigation.
Purpose of the Study:
- To evaluate the effect of topical flurbiprofen on trabeculectomy outcomes.
- To compare outcomes in patients receiving flurbiprofen versus placebo.
Main Methods:
- Prospective, placebo-controlled, randomized study.
- 49 eyes undergoing trabeculectomy.
- Standard postoperative medications included prednisolone, phenylephrine, atropine, and gentamycin.
- Flurbiprofen or artificial tear placebo was added postoperatively.
- Follow-up averaged 42 weeks.
Main Results:
- Intraocular pressure and visual acuity were not significantly different between flurbiprofen and placebo groups.
- Higher rates of encapsulated filtering blebs were observed in the flurbiprofen group (46% vs. 20%), a marginally significant difference (p=0.058).
- No other significant differences in adverse effects were noted.
Conclusions:
- Postoperative flurbiprofen does not offer additional benefit for trabeculectomy surgery.
- The potential for increased encapsulated filtering blebs warrants consideration.
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