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Examination of the MSX1 gene in patients with Parkinson's disease
1Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.
Background:
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.
Aims Of The Study:
To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.
Methods:
We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.
Results:
No mutation in the MSX1 gene was identified in our cohort.
Conclusions:
Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
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