Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plastic Deformations01:14

Plastic Deformations

It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
Plastic Deformations01:19

Plastic Deformations

Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their original...
Steps in the Modeling Process01:14

Steps in the Modeling Process

Albert Bandura's theory of observational learning identifies four critical processes: attention, retention, motor reproduction, and reinforcement or motivation.
Attention is the first necessary component for observational learning. It involves focusing on what the model is doing and saying. For example, if you decide to take a drawing class to enhance your skills, you need to pay close attention to the instructor's words and hand movements. The characteristics of the model significantly...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloid-specific interferon regulatory factor 5 promotes bone formation via orchestration of osteoclast lineage-osteoblast coupling.

The Journal of biological chemistry·2026
Same author

Targeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway.

Chinese journal of natural medicines·2026
Same author

Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity.

bioRxiv : the preprint server for biology·2025
Same author

Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation.

Acta pharmacologica Sinica·2025
Same author

An In Vitro Model of Murine Osteoclast-Mediated Bone Resorption.

Bio-protocol·2024

Related Experiment Video

Updated: Jun 18, 2026

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

Developmental ECM sculpting: laying it down and cutting it up.

Tamar Feinberg1, Stephen J Weiss

  • 1Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Developmental Cell
|November 20, 2009
PubMed
Summary

Proteolytic remodeling of the extracellular matrix (ECM) is crucial for embryonic development. New research highlights metalloproteinases (MT-MMPs and ADAMTS) as key regulators in mammalian morphogenesis and tissue remodeling.

More Related Videos

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
11:19

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
11:19

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Embryonic extracellular matrix (ECM) remodeling is vital for mammalian development.
  • The specific proteases orchestrating ECM modifications during morphogenesis have remained largely unidentified.

Discussion:

  • Two recent studies illuminate the roles of matrix metalloproteinases (MT-MMPs) and ADAMTS proteases.
  • These enzymes are implicated in critical developmental processes, including branching morphogenesis and interdigital web regression.

Key Insights:

  • MT-MMPs and ADAMTS family proteases are newly identified key players in embryonic ECM remodeling.
  • Their functions are essential for shaping tissues during embryonic development, such as limb formation and organ development.

Outlook:

  • Further investigation into MT-MMP and ADAMTS functions will clarify their precise mechanisms in morphogenesis.
  • Understanding these proteolytic pathways could offer insights into developmental disorders and regenerative medicine.