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Involvement of p34cdc2 in establishing the dependency of S phase on mitosis
D Broek1, R Bartlett, K Crawford
1Biochemistry Department, University of Oxford, UK.
Nature
|January 31, 1991
Abstract:
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.