Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute anti-obesity treatment with celastrol reduces body weight, cerebral inflammation and metabolic imbalances in mice.

Molecular medicine (Cambridge, Mass.)·2026
Same author

MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics.

Frontiers in immunology·2026
Same author

Cell-of-origin and genetic drivers define advanced bladder cancer subtypes and potential therapeutic response in mouse models.

Journal of experimental & clinical cancer research : CR·2026
Same author

Unaltered NKG2D-CAR T cell function under hypoxia in osteosarcoma in vitro.

Cancer immunology, immunotherapy : CII·2026
Same author

Zinc as a Biomarker of Nutritional Status and Clinical Burden in Recessive Dystrophic Epidermolysis Bullosa: Implications for Preventive Monitoring.

Nutrients·2026
Same author

Efficiency of ultrasound-guided placental gene therapy in a rabbit IUGR model and effects on offspring development.

Frontiers in veterinary science·2025

Related Experiment Video

Updated: Jun 18, 2026

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

Interplay between BMP4 and IL-7 in human intrathymic precursor cells.

Alberto Varas1, Rosa Sacedón, Laura Hidalgo

  • 1Department of Cell Biology, Faculty of Medicine, Complutense University, Madrid, Spain. avaras@bio.ucm.es

Cell Cycle (Georgetown, Tex.)
|November 20, 2009
PubMed
Summary

Bone morphogenetic protein 4 (BMP4) and Interleukin-7 (IL-7) signaling interplay maintains human thymic progenitor cells. BMP4 counteracts IL-7

More Related Videos

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Related Experiment Videos

Last Updated: Jun 18, 2026

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Signaling

Background:

  • Bone morphogenetic proteins (BMPs) are crucial for embryogenesis, organogenesis, and adult self-renewing tissues.
  • Components of the BMP2/4 signaling pathway are present in the human thymus.
  • Thymic progenitor cells are vital for T-cell development.

Purpose of the Study:

  • To investigate the role of BMP4 and IL-7 interplay in maintaining human thymic progenitor cells.
  • To elucidate the molecular mechanisms by which BMP4 affects thymic progenitor cell survival, proliferation, and differentiation.

Main Methods:

  • Analysis of BMP receptor and signaling molecule expression in human intrathymic CD34(+) cells.
  • In vitro experiments using BMP4 neutralization (Noggin) and exogenous BMP4.
  • Chimeric human-mouse fetal thymus organ culture treated with BMP4.

Main Results:

  • Intrathymic CD34(+) cells express BMP receptors, Smad molecules, and produce BMP4.
  • BMP4 neutralization reduces thymic precursor survival; exogenous BMP4 decreases proliferation.
  • BMP4 inhibits IL-7-induced proliferation and differentiation of CD34(+) cells by downregulating CD127 and STAT5 phosphorylation.

Conclusions:

  • BMP4 and IL-7 signaling have a critical interplay in maintaining the human thymic progenitor population.
  • BMP4 acts downstream of Sonic Hedgehog, modulating thymic progenitor cell fate.
  • Understanding this interplay is key for regenerative medicine and immunotherapy.