Related Experiment Video
Updated: Jun 18, 2026
Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Feasibility and safety of transcatheter intervention for complex patent ductus arteriosus
Shi-Wei Yang1, Yu-Jie Zhou, Da-Yi Hu
112th Ward, Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chao Yang District, Beijing, China.
Insights
Transcatheter intervention effectively treats complex patent ductus arteriosus (PDA) in adults. This safe procedure significantly reduces pulmonary pressure with a high success rate and minimal complications.
Area of Science:
- Cardiology
- Interventional Cardiology
- Adult Congenital Heart Disease
Background:
- Patent ductus arteriosus (PDA) can present complex challenges in adults.
- Transcatheter intervention offers a minimally invasive alternative to surgical repair.
Purpose of the Study:
- To evaluate the efficacy and safety of transcatheter intervention for complex PDA in adult Chinese patients.
- To assess procedural success rates, residual shunts, and hemodynamic changes post-intervention.
Main Methods:
- A retrospective analysis of 112 adult PDA patients undergoing transcatheter closure between January 2004 and April 2008.
- Utilized coils for small PDAs and Amplatzer or China-made occluders for moderate-to-large PDAs.
- Monitored procedural success, residual shunts, pulmonary pressures, and complications during follow-up.
Main Results:
- Achieved a high procedural success rate of 93.8% with low rates of residual shunts (8.0% initially, 1.8% at 12 months).
- Demonstrated a significant reduction in peak systolic pulmonary pressure (94 to 58 mm Hg, P < .001).
- Reported no severe procedure-related complications; minor complications like hemolysis were managed conservatively.
Conclusions:
- Transcatheter intervention is a safe and effective treatment for adult patients with complex PDA.
- The procedure leads to significant hemodynamic improvement and is well-tolerated in this population.
Abstract:
We evaluated the transcatheter intervention of complex patent ductus arteriosus (PDA) in Chinese adults. Between January 2004 and April 2008, 112 adult patients (43 males, 69 females, mean age 31 +/- 19 years) underwent intervention. Coils were used for patients with small PDA, and Amplatzer duct occluders or China-made mushroom-shaped occluders were used for patients with moderate-to-large PDA. The success rate of transcatheter intervention was 93.8%, and 9 patients (8.0%) had small residual shunts. At the end of 12 months follow-up, the rate of residual shunts was 1.8%. Peak systolic pulmonary pressure decreased from 94 +/- 21 mm Hg preintervention to 58 +/- 20 mm Hg postintervention (P < .001). No severe procedure-related complications (including death, dislocation of occluders, stenosis of aorta or pulmonary artery) occurred. Some patients developed hemolysis or vascular access complications, all resolved by conservative therapy. Transcatheter intervention is an effective and safe treatment for adult PDA patients with complex anatomic or hemodynamic conditions.
