Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...

Drug toxicity: Drug–Drug Interaction

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...

Combined Effects of Drugs: Antagonism

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An Evaluation of a New Ultrasonic Water Irrigator in the Management of Gingival Health: A Randomised Study.

International journal of dental hygiene·2024

Same author

Full-Mouth Disinfection.

Dental update·2017

Same author

Antibiotics in dentistry--an update.

Dental update·2013

Same author

The prevalence of dysplasia and malignant lip lesions in transplant patients.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2011

Same author

Is oral health a risk for malignant disease?

Dental update·2010

Same author

Does periodontal treatment improve general health?

Dental update·2010

Same journal

Technique Tips – Iatrogenesis and How to Prevent It.

Dental update·2017

Same journal

Clinical Challenges Q&A 31. Painful Lip.

Dental update·2017

Same journal

Dual Role of Subepithelial Connective Tissue Grafting in Regeneration of Periodontal Attachment Apparatus.

Dental update·2017

Same journal

Ceramic Fracture in Metal-Ceramic Restorations: The Aetiology.

Dental update·2017

Same journal

Arteriovenous Malformation of the Jaws: a Black Hole for the GDP – A Case Report.

Dental update·2017

Same journal

The Immune System: Basis of so much Health and Disease: 4. Immunocytes.

Dental update·2017

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Drug interactions in dentistry.

Robin A Seymour¹

¹School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK.

|November 26, 2009

Summary

This summary is machine-generated.

Dental patients on multiple medications face risks of drug interactions. Dentists can prevent these by taking thorough patient drug histories and understanding common interaction mechanisms.

Related Experiment Videos

Last Updated: Jun 18, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Area of Science:

Pharmacology
Dental Medicine

Background:

Growing number of patients use multiple medications.
Potential for drug interactions between prescribed dental drugs and patient's existing medications.

Purpose of the Study:

To address and quantify risks of drug interactions in dental practice.
To discuss mechanisms and highlight drug categories prone to interactions.

Main Methods:

Review of drug interactions relevant to dentistry.
Discussion of interaction mechanisms.
Identification of high-risk drug categories.

Main Results:

Drug interactions in dentistry are common due to polypharmacy.
Specific drug classes are more frequently involved in interactions.
Most dental drug interactions are preventable.

Conclusions:

Understanding drug interactions is crucial for safe dental practice.
Thorough and regular patient drug history is essential for prevention and management.