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Updated: Jun 18, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

[Polymorphous low-grade adenocarcinoma: about two cases].

Lobna Ayadi¹, Salma Chaâbouni, Houria Dhouib

¹Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Habib Bourguiba, Sfax.

La Tunisie Medicale

|November 26, 2009

Summary

Polymorphous low-grade adenocarcinoma (APBG) is a rare salivary gland tumor. Early diagnosis and wide surgical excision are crucial for managing this infiltrative malignancy.

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Last Updated: Jun 18, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Polymorphous low-grade adenocarcinoma (APBG) is a rare malignant tumor of minor salivary glands.
This tumor commonly arises in the palate.

Observation:

Two cases of APBG are presented: one in the palate of a 65-year-old woman with recurrence after treatment, and another in the lower lip of a 57-year-old woman with no evidence of disease.
The palatal tumor was initially misdiagnosed as pleomorphic adenoma, highlighting diagnostic challenges.

Findings:

APBG exhibits morphologic diversity and cytologic uniformity, complicating differential diagnosis with tumors like adenoid cystic carcinoma and pleomorphic adenoma.
The palatal APBG showed lymph node metastasis and local recurrence, indicating aggressive behavior.
The lower lip APBG was completely resected and showed no recurrence after 54 months.

Implications:

Accurate diagnosis of APBG is essential due to its infiltrative growth pattern and potential for recurrence.
Wide surgical excision is the primary treatment modality for APBG.
Adjuvant radiotherapy may be considered in cases with metastasis or incomplete resection.