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Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac output averages...
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Pulse01:05

Pulse

The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls between...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...
Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...

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Related Experiment Video

Updated: Jun 18, 2026

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
06:10

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion

Published on: June 28, 2024

Simple method for evaluating cardiac output.

Watts R Webb1, Peter V Moulder, Lynn H Harrison

  • 1Louisiana State University Health Sciences Center, New Orleans, USA.

The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

A modified Starr formula accurately calculates cardiac output using patient size, offering a non-invasive alternative to thermal dilution. This method shows high accuracy for clinical use in intensive care units.

More Related Videos

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
08:01

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Published on: June 11, 2020

Related Experiment Videos

Last Updated: Jun 18, 2026

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
06:10

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion

Published on: June 28, 2024

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
08:01

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Published on: June 11, 2020

Area of Science:

  • Cardiovascular Physiology
  • Medical Device Technology

Background:

  • Accurate cardiac output measurement is crucial in intensive care units (ICUs).
  • Standard methods like thermal dilution can be invasive and resource-intensive.
  • Non-invasive alternatives are sought for routine clinical monitoring.

Purpose of the Study:

  • To evaluate the accuracy of a modified Starr pulse pressure formula for calculating cardiac output.
  • To compare this modified formula against the standard thermal dilution technique.
  • To assess the clinical applicability of a non-invasive method for cardiac output determination.

Main Methods:

  • A modified Starr formula incorporating patient body surface area (BSA) was used.
  • Stroke volume was calculated using the formula: (100 - 0.6*age - 0.6*Diastolic Pressure + 0.5*Pulse Pressure) * BSA / 1.7.
  • Cardiac output was determined by multiplying stroke volume by heart rate.
  • Measurements were compared with a standard thermal dilution technique in 111 ICU patients.

Main Results:

  • Over 90% of patients showed less than a 10% variance between the modified formula and thermal dilution.
  • Approximately 60% of patients had a difference of less than 5%.
  • The maximum variation observed in this patient cohort was 18%.

Conclusions:

  • The modified Starr formula provides accurate cardiac output estimations suitable for clinical use.
  • This non-invasive method relies on readily available sphygmomanometer blood pressure measurements.
  • The formula offers a practical alternative for monitoring cardiac output in surgical and critically ill patients.