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Related Concept Videos

ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

4.9K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
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ATP Driven Pumps II: P-type Pumps01:34

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
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Related Experiment Video

Updated: Feb 23, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

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Findlay Implantable Two-Stage Centrifugal Pump.

Peter V Moulder1, Iain S Findlay1, Robert M Zone1

  • 1Louisiana State University and the New Orleans Veterans Administration Medical Center, Division of Cardiothoracic Surgery, U.S.ATulane University Department of Biomedical Engineering, U.S.AMid Continent Laboratories, New Orleans, LA, U.S.AVital Assist, Inc., New Orleans, LA, U.S.A.

Artificial Organs
|September 5, 2017
PubMed
Summary
This summary is machine-generated.

The Findlay centrifugal pump offers efficient, two-stage blood pumping with minimal hemolysis. This implantable device shows promise for ventricular assist systems.

Keywords:
Blood flow-Centrifugal pump-Lift force pump-Pump-induced hemolysisShear pump-Ventricular assist system-

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices

Background:

  • Ventricular assist devices (VADs) are crucial for supporting failing hearts.
  • Improving VAD efficiency and minimizing blood damage are key research areas.

Purpose of the Study:

  • To evaluate the performance and hemocompatibility of the novel Findlay centrifugal pump.
  • To assess its suitability for use in ventricular assist systems.

Main Methods:

  • Fabrication and analysis of 26 prototype Findlay centrifugal pumps.
  • Hemolysis testing and hydraulic performance evaluation.
  • Acute studies in normal dogs utilizing the pump in a ventricular assist system.

Main Results:

  • The two-stage pump design (lift force and shear force) demonstrated high efficiency.
  • Minimal hemolysis (3.5-5 h) was observed in tested pumps.
  • Flow rates up to 10 L/min for water and 1.2-4.5 L/min for blood were achieved at modest speeds.

Conclusions:

  • The Findlay pump exhibits low blood damage and acceptable hydraulic efficiency.
  • Its small, implantable design and performance make it a viable candidate for VAD applications.