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Acute Right Ventricular Failure in Animal Models: Evidence, Limitations, and Future Directions
Paolo Manca1,2,3, Vincenzo Nuzzi1,2, Antonella Peccianti4
1IRCCS ISMETT, Palermo, Italy.
Artificial Organs
|August 7, 2026
Summary
Acute right ventricular failure (ARVF) treatment is evolving with mechanical circulatory support (MCS). Current animal models for ARVF are limited, hindering the development of optimal MCS strategies and evidence-based clinical guidelines.
Area of Science:
- Cardiology
- Critical Care Medicine
- Translational Research
Background:
- Acute right ventricular failure (ARVF) is a critical condition often requiring mechanical circulatory support (MCS).
- Significant advancements in MCS devices offer new treatment avenues for severe ARVF.
- Comparative clinical data on the efficacy of different MCS strategies are currently lacking.
Purpose of the Study:
- To review and critically evaluate existing animal models of ARVF.
- To examine the integration and effectiveness of MCS within these preclinical models.
- To identify limitations in current ARVF models and advocate for improved preclinical research.
Main Methods:
- Systematic review of literature on ARVF animal models.
- Analysis of studies incorporating MCS in ARVF models.
- Critical appraisal of methodological strengths and limitations of existing models.
Main Results:
- Existing ARVF animal models vary in their ability to replicate critical aspects of the human condition, such as ventricular-pulmonary artery uncoupling and cardiogenic shock.
- Limited studies have incorporated MCS devices, and direct comparisons between different support strategies are scarce.
- Preclinical research gaps hinder the development of evidence-based algorithms for right-sided MCS deployment.
Conclusions:
- There is an urgent need for standardized, reproducible, and clinically relevant ARVF animal models.
- Improved preclinical models are essential for advancing the understanding and treatment of ARVF.
- Optimizing MCS device selection and application through better research can enhance patient outcomes in ARVF.
