Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-resistance coils in E-cigarettes increase heavy metals leaching into aerosols to cause oxidants generation in human bronchial epithelial cells at air-liquid interface: A unique non-animal methodological approach on vaping studies.

NAM journal·2026
Same author

The protracted neurotoxic consequences in mice of developmental exposures to inhaled iron nanoparticles alone or in combination with SO<sub>2</sub>.

Frontiers in behavioral neuroscience·2025
Same author

Correction to: Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria.

Archives of toxicology·2025
Same author

Assessment of household settled dust via silicon nanomembrane analysis pipeline (SNAP).

Environmental technology & innovation·2025
Same author

Brain iron accumulation in neurodegenerative disorders: Does air pollution play a role?

Particle and fibre toxicology·2025
Same author

Understanding Human Health Impacts Following Microplastic Exposure Necessitates Standardized Protocols.

Current protocols·2024

Related Experiment Video

Updated: Jun 18, 2026

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

Nanoparticles and the brain: cause for concern?.

Günter Oberdörster1, Alison Elder, Amber Rinderknecht

  • 1University of Rochester, Department of Environmental Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA.

Journal of Nanoscience and Nanotechnology
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

Engineered nanoparticles (NPs) can enter the body and potentially reach the brain, posing risks. Understanding NP translocation and surface properties is key to assessing neurotoxic effects and preventing exposure.

More Related Videos

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
08:37

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

Preparation of Neuronal Co-cultures with Single Cell Precision
09:06

Preparation of Neuronal Co-cultures with Single Cell Precision

Published on: May 20, 2014

Related Experiment Videos

Last Updated: Jun 18, 2026

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
08:37

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

Preparation of Neuronal Co-cultures with Single Cell Precision
09:06

Preparation of Neuronal Co-cultures with Single Cell Precision

Published on: May 20, 2014

Area of Science:

  • Nanotechnology
  • Toxicology
  • Neuroscience

Background:

  • Engineered nanoparticles (NPs) share size characteristics with atmospheric ultrafine particles (<100 nm).
  • NPs exhibit high surface area to volume ratios, leading to increased chemical and biological activity, including reactive oxygen species induction.
  • Inhaled NPs can deposit throughout the respiratory tract and translocate across biological barriers.

Purpose of the Study:

  • To explore the translocation of nanoparticles from the respiratory tract to secondary organs, including the central nervous system (CNS).
  • To investigate the mechanisms and factors influencing NP entry into cells and association with subcellular structures.
  • To assess the potential neurotoxic effects of inhaled NPs and the implications for human health.

Main Methods:

  • Review of NP deposition, translocation, and cellular uptake mechanisms.
  • Analysis of NP interaction with biological barriers, including the blood-brain barrier via neuronal pathways.
  • Consideration of physicochemical properties (size, surface chemistry) and their impact on NP biokinetics.

Main Results:

  • NPs can translocate from the entry portal to secondary organs and enter cells.
  • Neuronal transport offers a pathway for NPs to access the CNS, bypassing the blood-brain barrier.
  • Translocation rates are generally low but influenced by NP characteristics and surface coatings.
  • Species differences in anatomy and physiology impact the extrapolation of NP effects from animal models to humans.

Conclusions:

  • Inhaled NPs possess the potential for CNS exposure and adverse effects like oxidative stress.
  • Further research is needed to confirm the link between NP exposure and neurodegenerative diseases.
  • Identifying hazardous NPs and implementing exposure prevention measures are crucial for mitigating risks.