Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Digital Immunoassays for Sensitive Quantification of Blood Biomarkers Using Solid-State Nanopores.

ACS nano·2026

Same author

Effects of Isothermal Treatment on A<sub>g</sub>ZIF-62: Implications on Porosity, Separations, and Grain Boundary Defect Removal.

Small science·2026

Same author

Catch-and-Display Immunoassay as an Accessible Platform for Digital Biomarker Detection.

bioRxiv : the preprint server for biology·2026

Same author

High-resistance coils in E-cigarettes increase heavy metals leaching into aerosols to cause oxidants generation in human bronchial epithelial cells at air-liquid interface: A unique non-animal methodological approach on vaping studies.

NAM journal·2026

Same author

Structural similarity networks reveal brain vulnerability in dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

New infant formulas for healthy term infants: A randomized, controlled, double-blind, multicenter, non-inferiority design safety study.

PloS one·2025

Search research articles

Related Experiment Video

Updated: May 2, 2026

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

Understanding Human Health Impacts Following Microplastic Exposure Necessitates Standardized Protocols.

Sarah E Morgan¹, Samantha S Romanick², Lisa DeLouise³

¹Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York, United States.

Current Protocols

|July 17, 2024

Summary

This summary is machine-generated.

Microplastics (MPs) are a growing environmental concern. This study reviews methods for assessing MP bioactivity, highlighting challenges and proposing standardization for reliable research on human health impacts.

Keywords:

bioavailability dosimetry exposure microplastics reference materials

More Related Videos

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

Sampling, Identification and Characterization of Microplastics Release from Polypropylene Baby Feeding Bottle during Daily Use

Sampling, Identification and Characterization of Microplastics Release from Polypropylene Baby Feeding Bottle during Daily Use

Published on: July 24, 2021

Related Experiment Videos

Last Updated: May 2, 2026

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

Sampling, Identification and Characterization of Microplastics Release from Polypropylene Baby Feeding Bottle during Daily Use

Sampling, Identification and Characterization of Microplastics Release from Polypropylene Baby Feeding Bottle during Daily Use

Published on: July 24, 2021

Area of Science:

Environmental Science
Toxicology
Biotechnology

Background:

Microplastics (MPs) are pervasive pollutants with documented human exposure routes.
Understanding the biological implications of MP exposure is crucial due to their persistence.
MP impacts depend on particle properties, dose, and exposure routes.

Purpose of the Study:

To provide a perspective on current methods for assessing microplastic bioactivity.
To identify challenges in microplastic bioactivity research.
To propose solutions for standardizing microplastic research.

Main Methods:

Review of assays, exposure conditions, and reference MP particles used in bioactivity studies.
Analysis of challenges related to instrumentation, reference materials, and dosimetry.
Discussion of proposed solutions for enhancing study applicability and reducing redundancy.

Main Results:

A wide variety of assays and exposure conditions are currently employed.
Significant challenges exist due to instrumentation, lack of standardized materials, and dosimetry.
Proposed solutions aim to improve consistency and comparability across studies.

Conclusions:

Standardization of methods is essential for advancing microplastic bioactivity research.
Addressing current challenges will lead to a more reliable knowledge base.
Future studies should focus on reproducible and standardized protocols.