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Recombinant activated factor VII controls chemotherapy-related hemorrhage in patients with solid intra-abdominal

Ernest Bilić1, Ljubica Rajić, Ranka Femenić

  • 1Department of Pediatric Hematology and Oncology, University Department of Pediatrics, Zagreb University Hospital Center, Zagreb, Croatia. ernest.bilic@zg.t-com.hr

Acta Clinica Croatica
|November 26, 2009
PubMed

Recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark) is used predominantly for the treatment of bleeding in patients with hemophilia and inhibitors, and in patients with traumatic injury. There are also literature reports of its use in chemotherapy-related bleeding in leukemia patients and intra- or postoperative bleeding in patients with solid tumors. We describe three pediatric patients where rFVIIa was successfully used to manage bleeding following the failure of conventional hemostatic treatments during chemotherapy for intra-abdominal tumors (hepatoblastoma, rhabdomyosarcoma and non-classified malignant sarcoma). Recombinant FVIIa proved effective and maintained hemostasis in two of three cases, with no evidence for toxic or adverse events in any of the treated patients.

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